Open AccessSpatial Normalization Using Early-Phase [18F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding
Author(s) -
Sungwoo Bae,
Hongyoon Choi,
Wonseok Whi,
Jin Chul Paeng,
Gi Jeong Cheon,
Keon Wook Kang,
Dong Hoon Lee
Publication year - 2020
Publication title -
nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 23
eISSN - 1869-3482
pISSN - 1869-3474
DOI - 10.1007/s13139-020-00669-0
Subject(s) - dopamine transporter , putamen , medicine , normalization (sociology) , nuclear medicine , spatial normalization , positron emission tomography , intraclass correlation , binding potential , magnetic resonance imaging , radiology , dopaminergic , dopamine , clinical psychology , sociology , anthropology , psychometrics
The precise quantification of dopamine transporter (DAT) density on N -(3-[ 18 F]Fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane positron emission tomography ([ 18 F]FP-CIT PET) imaging is crucial to measure the degree of striatal DAT loss in patients with parkinsonism. The quantitative analysis requires a spatial normalization process based on a template brain. Since the spatial normalization method based on a delayed-phase PET has limited performance, we suggest an early-phase PET-based method and compared its accuracy, referring to the MRI-based approach as a gold standard.