Spatial Normalization Using Early-Phase [18F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding | Zendy

Sungwoo Bae | Zendy; Hongyoon Choi | Zendy; Wonseok Whi | Zendy; Jin Chul Paeng | Zendy; Gi Jeong Cheon | Zendy; Keon Wook Kang | Zendy; Dong Soo Lee | Zendy

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Spatial Normalization Using Early-Phase [18F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding

Author(s) -

Sungwoo Bae,

Hongyoon Choi,

Wonseok Whi,

Jin Chul Paeng,

Gi Jeong Cheon,

Keon Wook Kang,

Dong Soo Lee

Publication year - 2020

Publication title -

nuclear medicine and molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.534

H-Index - 23

eISSN - 1869-3482

pISSN - 1869-3474

DOI - 10.1007/s13139-020-00669-0

Subject(s) - dopamine transporter , putamen , medicine , normalization (sociology) , nuclear medicine , spatial normalization , positron emission tomography , intraclass correlation , binding potential , magnetic resonance imaging , radiology , dopaminergic , dopamine , clinical psychology , sociology , anthropology , psychometrics

The precise quantification of dopamine transporter (DAT) density on N -(3-[ 18 F]Fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane positron emission tomography ([ 18 F]FP-CIT PET) imaging is crucial to measure the degree of striatal DAT loss in patients with parkinsonism. The quantitative analysis requires a spatial normalization process based on a template brain. Since the spatial normalization method based on a delayed-phase PET has limited performance, we suggest an early-phase PET-based method and compared its accuracy, referring to the MRI-based approach as a gold standard.

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