Open Access68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?
Author(s) -
Thabo Lengana,
Ismaheel O. Lawal,
Kgomotso Mokoala,
Mariza Vorster,
Mike Sathekge
Publication year - 2019
Publication title -
nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 23
eISSN - 1869-3482
pISSN - 1869-3474
DOI - 10.1007/s13139-019-00621-x
Subject(s) - medicine , thyroid cancer , refractory (planetary science) , papillary thyroid cancer , thyroglobulin , nuclear medicine , radioactive iodine , thyroid , thyroidectomy , radiology , iodine , physics , materials science , astrobiology , metallurgy
We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of 131 I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a 123 I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both 18 F-FDG and 68 Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the 68 Ga-PSMA study.