Open AccessOrbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
Author(s) -
Saurabh Arora,
Nishikant Damle,
Rachna Meel,
Sanjay Sharma,
Seema Sen,
Chandersekhar Bal,
Kusum Lata,
Sneha Prakash,
Divya Yadav,
Meivel Angamuthu
Publication year - 2019
Publication title -
nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 23
eISSN - 1869-3482
pISSN - 1869-3474
DOI - 10.1007/s13139-019-00611-z
Subject(s) - medicine , igg4 related disease , autoimmune pancreatitis , pathology , somatostatin receptor , broad spectrum , extraocular muscles , radiology , disease , somatostatin , ophthalmology , chemistry , combinatorial chemistry
Immunoglobulin G4 (IgG4)-related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using 68 Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).