Open AccessApigenin effect against Leishmania tropica amastigotes in vitro
Author(s) -
Nagham Naddaf,
Shaden Haddad
Publication year - 2020
Publication title -
journal of parasitic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 21
eISSN - 0975-0703
pISSN - 0971-7196
DOI - 10.1007/s12639-020-01230-8
Subject(s) - apigenin , amastigote , leishmania tropica , cutaneous leishmaniasis , leishmaniasis , leishmania , pharmacology , leishmania major , medicine , biology , immunology , biochemistry , flavonoid , parasite hosting , world wide web , computer science , antioxidant
Cutaneous Leishmaniasis is a current public health problem in Syria. It causes different skin lesions that vary in their severity from spontaneously heal lesions to permanent deformity ones. However, the used treatments have many disadvantages as their high toxicity and many side effects. Flavonoids including Apigenin reported to have many anti parasitic properties. As well as their preference as potential therapeutic alternatives in the treatment of Leishmaniasis due to its low side effects and toxicity. This study aims to evaluate the efficacy of Apigenin against L.tropica amastigotes in vitro using Leishmania-Macrophage Interaction Assay. Our study demonstrated the possibility of efficacy of Apigenin against L.tropica amastigotes since Apigenin reduced the infection index at IC 50 60.44 µM and this requires subsequent studies in humans and using Apigenin as a candidate for the chemotherapeutic treatment against Leishmaniasis.