Open AccessRegulation of the glucose supply from capillary to tissue examined by developing a capillary model
Author(s) -
Akinori Maeda,
Yukiko Himeno,
Masayuki Ikebuchi,
Akinori Noma,
Atsushi Amano
Publication year - 2017
Publication title -
journal of physiological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.968
H-Index - 49
eISSN - 1880-6562
pISSN - 1880-6546
DOI - 10.1007/s12576-017-0538-8
Subject(s) - capillary action , diffusion , saturation (graph theory) , convection , glucose transporter , chemistry , flux (metallurgy) , chromatography , biophysics , mechanics , endocrinology , biology , thermodynamics , mathematics , insulin , physics , organic chemistry , combinatorics
A new glucose transport model relying upon diffusion and convection across the capillary membrane was developed, and supplemented with tissue space and lymph flow. The rate of glucose utilization (J util ) in the tissue space was described as a saturation function of glucose concentration in the interstitial fluid (C glu,isf ), and was varied by applying a scaling factor f to J max . With f = 0, the glucose diffusion ceased within ~20 min. While, with increasing f, the diffusion was accelerated through a decrease in C glu,isf , but the convective flux remained close to resting level. When the glucose supplying capacity of the capillary was measured with a criterion of J util /J max = 0.5, the capacity increased in proportion to the number of perfused capillaries. A consistent profile of declining C glu,isf along the capillary axis was observed at the criterion of 0.5 irrespective of the capillary number. Increasing blood flow scarcely improved the supplying capacity.