Open AccessFunctiogenesis of cardiac pacemaker activity
Author(s) -
Tetsuro Sakai,
Kohtaro Kamino
Publication year - 2015
Publication title -
journal of physiological sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.968
H-Index - 49
eISSN - 1880-6562
pISSN - 1880-6546
DOI - 10.1007/s12576-015-0431-2
Subject(s) - electrophysiology , pacemaker potential , cardiac pacemaker , morphogenesis , function (biology) , biology , neuroscience , anatomy , cardiology , medicine , microbiology and biotechnology , biochemistry , gene
Throughout our investigations on the ontogenesis of the electrophysiological events in early embryonic chick hearts, using optical techniques to record membrane potential probed with voltage-sensitive dyes, we have introduced a novel concept of "functiogenesis" corresponding to "morphogenesis". This article gives an account of the framework of "functiogenesis", focusing on the cardiac pacemaker function and the functional organization of the pacemaking area.