Open AccessPostnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol
Author(s) -
Vanessa Pereira Teixeira,
Daniela A. B. Cervilha,
Layla D.M. Cabral,
Luíz M. Oliveira,
Erika K. Incerpi,
Rômulo Dias Novaes,
Marisa Ionta,
Roseli Soncini
Publication year - 2015
Publication title -
journal of physiological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.968
H-Index - 49
eISSN - 1880-6562
pISSN - 1880-6546
DOI - 10.1007/s12576-015-0417-0
Subject(s) - methacholine , bronchoconstriction , salbutamol , medicine , airway resistance , respiratory physiology , elastic recoil , lung , overnutrition , endocrinology , asthma , respiratory disease , obesity
Obesity increases the risk of respiratory disease, which is associated with airway hyperresponsiveness. Although the molecular underpinnings of this phenomenon are not well established, lung remodeling is known as an important factor in this process and could potentially explain compromised lung functions. In the present study, the obesity was induced by postnatal overnutrition in Swiss mice and we investigated the pulmonary mechanics after aerosolization of saline, methacholine, and salbutamol. The lungs were prepared for morphometric analysis. Obese animals showed bronchoconstriction in response to methacholine, as evidenced by airway and tissue resistance, tissue elastance, and hysteresivity. Salbutamol was effective at recovering the response only for airway resistance but not for tissue mechanics. We suggest that this impaired response in obese mice is related to collapsed alveolar, to inflammatory cells, and to elevated deposition collagen fibers in parenchymal tissue.