Open AccessMORC2 Interactome: Its Involvement in Metabolism and Cancer
Author(s) -
Rohith Kumar Guddeti,
Namita Chutani,
Suresh B. Pakala
Publication year - 2021
Publication title -
biophysical reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.766
H-Index - 39
eISSN - 1867-2469
pISSN - 1867-2450
DOI - 10.1007/s12551-021-00812-x
Subject(s) - interactome , chromatin remodeling , reprogramming , chromatin , microbiology and biotechnology , epigenetics , carcinogenesis , mef2c , metastasis , biology , computational biology , cancer , transcription factor , dna , biochemistry , genetics , cell , gene
Microrchidia 2 (MORC2) is an emerging chromatin modifier with a role in chromatin remodeling and epigenetic regulation. MORC2 is found to be upregulated in most cancers, playing a significant role in tumorigenesis and tumor metastasis. Recent studies have demonstrated that MORC2 is a scaffolding protein, which interacts with the proteins involved in DNA repair, chromatin remodeling, lipogenesis, and glucose metabolism. In this review, we discuss the domain architecture and cellular and subcellular localization of MORC2. Further, we highlight MORC2-specific interacting partners involved in metabolic reprogramming and other pathological functions such as cancer progression and metastasis.