Open AccessSuccessful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome
Author(s) -
Shimoda Misato,
Iwayama Hiroshi,
Ishiyama Mai,
Nakatani Ayano,
Yamashita Masanori
Publication year - 2016
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-015-0214-8
Subject(s) - reproductive medicine , pregnancy , embryo transfer , medicine , kallmann syndrome , andrology , gynecology , embryo , obstetrics , biology , microbiology and biotechnology , genetics , disease , covid-19 , infectious disease (medical specialty)
Purpose Kallmann syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. We report the case of a 31‐year‐old woman with Kallmann syndrome who successfully gave birth after intracytoplasmic sperm injection (ICSI) and vitrified–warmed embryo transfer, despite relatively ineffective ovarian stimulation. Method A 30 year‐old woman with primary amenorrhea wished to achieve pregnancy. Diagnostic testing results were consistent with Kallmann syndrome. Follicular stimulation was started with human menopausal gonadotropin (hMG; 150 IU/day). After 28 days of treatment, 4 follicles were observed (total hMG; 4200 IU), with a dominant follicle diameter of 23 mm. Ovum pick‐up was performed and 2 oocytes, one at metaphase II (MII) and one at the germinal vesicle stage, were obtained. Piezo‐ICSI was performed on the MII oocyte and an 8‐cell stage embryo was cryopreserved on day 3. Subsequently, embryo transfer was performed after endometrial preparation. Result A gestational sac and embryo heart activity were confirmed by ultrasonographic monitoring, and a healthy male infant weighing 3246 g was delivered by Caesarean section after 41 weeks 3 days of gestation. Conclusion This is the first report of a healthy delivery after vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified–warmed embryo transfer are effective for women with Kallmann syndrome.