Open AccessA case of primary ciliary dyskinesia treated with ICSI using testicular spermatozoa: case report and a review of the literature
Author(s) -
Kawasaki Akiko,
Okamoto Hajime,
Wada Atsushi,
Ainoya Yoko,
Kita Naoki,
Maeyama Tetsuro,
Edamoto Naoko,
Nishiyama Hiroyuki,
Tsukamoto Sadamu,
Joraku Akira,
Waku Natsui,
Yoshikawa Hiroyuki
Publication year - 2015
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-015-0210-z
Subject(s) - intracytoplasmic sperm injection , primary ciliary dyskinesia , medicine , pregnancy , human fertilization , pregnancy rate , andrology , live birth , gynecology , infertility , biology , anatomy , genetics , bronchiectasis , lung
Purpose To investigate whether or not intracytoplasmic sperm injection (ICSI) using spermatozoa extracted from testis (TESE‐ICSI) is a more effective treatment than ICSI with ejaculated spermatozoa (EJ‐ICSI) for primary ciliary dyskinesia (PCD). Methods We reported a case of PCD in which we performed TESE‐ICSI after repeated failure of EJ‐ICSI. Together with data from previous case reports, we compared the fertilization rate and pregnancy outcome of TESE‐ICSI and EJ‐ICSI. Results In our case, TESE‐ICSI improved the morphology of spermatozoa and fertilization rate. However, the outcome was only a biochemical pregnancy. According to the analysis combined with previous reports, there was no difference in the fertilization rate and pregnancy outcome parameters between TESE‐ICSI and EJ‐ICSI. Conclusions TESE‐ICSI for PCD may improve the fertilization rate compared to EJ‐ICSI. However, it does not necessarily improve the pregnancy outcome for a patient with primary ciliary dyskinesia.