Open AccessCabergoline administration prevents development of moderate to severe ovarian hyperstimulation syndrome and it contributes to reduction in ovarian volume
Author(s) -
Inoue Tomoko,
Hashimoto Shu,
Iwahata Hideyuki,
Ito Keijiro,
Nakaoka Yoshiharu,
Morimoto Yoshiharu
Publication year - 2015
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-014-0198-9
Subject(s) - cabergoline , ovarian hyperstimulation syndrome , medicine , ovulation , oocyte , in vitro fertilisation , ovulation induction , agonist , gonadotropin releasing hormone agonist , gynecology , endocrinology , hormone , urology , gonadotropin releasing hormone , pregnancy , biology , embryo , luteinizing hormone , receptor , prolactin , genetics , microbiology and biotechnology
Purpose The aim of this study was to determine the prophylactic effects of cabergoline on ovarian hyperstimulation syndrome (OHSS) after oocyte retrieval. Methods A total of 187 women underwent controlled ovarian stimulation using gonadotropin releasing hormone (GnRH) agonist long protocol or flexible GnRH antagonist protocol for in vitro fertilization. They responded excessively to ovulation induction, and fresh embryo transfers were canceled. Sixty‐one patients in the intervention group were administered oral cabergoline (0.5 mg) three times after oocyte retrieval (day 0, 2, and 4 following the oocyte retrieval). Ultrasonography and blood examination were performed on the seventh day following oocyte retrieval. The main outcomes measured were the incidence of OHSS, estimated ovarian volumes, ascites, hematocrits, and white blood cell counts. Results The incidence of moderate to severe OHSS was lower after cabergoline administration (9.8 vs. 23.0 %, p = 0.03). The ovarian volumes reduced after intervention (96.2 vs. 145.5 cm 3 , p = 0.008). The reduction was evident in the patients with agonist long protocol (92.1 vs. 167.5 cm 3 , p = 0.0005). No significant differences were observed for other factors. Conclusions Cabergoline has a favorable effect on the prevention of moderate to severe OHSS affiliated with ovarian volume reduction.