Open AccessUterine receptivity and embryo–uterine interactions in embryo implantation: lessons from mice
Author(s) -
Egashira Mahiro,
Hirota Yasushi
Publication year - 2013
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-013-0153-1
Subject(s) - embryo , reproductive medicine , andrology , gynecology , receptivity , embryo transfer , medicine , pregnancy , biology , microbiology and biotechnology , genetics
Implantation is a process of the first feto‐maternal encounter in the uterus. A competent blastocyst and a receptive uterus are critical for successful implantation. For an acquisition of uterine receptivity, the following conditions need to be satisfied in the uterine environments: the endometrial preparation with stromal proliferation and epithelial differentiation in the pre‐receptive phase and proper interactions between the uterus and blastocyst later in the phase. Focusing on these points and primarily referring to the mouse in vivo evidence, this review article has shown detailed molecular mechanisms for successful implantation.