Open AccessComparison between the gonadotropin‐releasing hormone antagonist protocol and the gonadotropin‐releasing hormone agonist long protocol for controlled ovarian hyperstimulation in the first in vitro fertilization–embryo transfer cycle in an unspecified population of infertile couples
Author(s) -
Mekaru Keiko,
Yagi Chiaki,
Asato Kozue,
Masamoto Hitoshi,
Sakumoto Kaoru,
Aoki Yoichi
Publication year - 2012
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-011-0109-2
Subject(s) - ovarian hyperstimulation syndrome , controlled ovarian hyperstimulation , in vitro fertilisation , agonist , gonadotropin releasing hormone antagonist , gonadotropin releasing hormone , gonadotropin releasing hormone agonist , medicine , embryo cryopreservation , antagonist , embryo transfer , live birth , andrology , hormone antagonist , endocrinology , hormone , biology , pregnancy , luteinizing hormone , receptor , genetics
Purpose We aimed to compare the efficacy of a gonadotropin‐releasing hormone (GnRH) antagonist protocol and a GnRH agonist long protocol used in the first in vitro fertilization–embryo transfer (IVF–ET) cycle in an unspecified population of infertile couples. Methods Fifty and 34 patients were treated with a GnRH agonist long protocol (agonist group) and GnRH antagonist protocol (antagonist group), respectively, in the first treatment cycle. The primary and secondary outcome measures were cumulative live birth rates after fresh and cryopreserved–thawed ETs and incidence of grades II and III ovarian hyperstimulation syndrome (OHSS), respectively. Results No significant differences were observed in clinical pregnancy rates (38.0 vs. 32.4%) and live birth rates (22.0 vs. 23.5%), which included both fresh and cryopreserved–thawed ETs, between the 2 groups. However, the incidence of grade III OHSS was significantly lower with the GnRH antagonist protocol than the GnRH agonist long protocol. Conclusions Used in the first IVF–ET cycle in an unspecified population of infertile patients, the GnRH antagonist protocol showed the same clinical outcome as the GnRH agonist long protocol.