Open AccessCancellation of in vitro fertilization treatment cycles predicts treatment outcome in female infertility patients aged 40 years or older
Author(s) -
Sugimoto Kouhei,
Hashimoto Tomoko,
Takahashi Eri,
Saito Yukiyo,
Haino Takayuki,
Sasaki Hiroshi,
Kusuhara Koji,
Tanaka Tadao
Publication year - 2011
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1007/s12522-011-0089-2
Subject(s) - infertility , in vitro fertilisation , medicine , live birth , embryo transfer , pregnancy , pregnancy rate , gynecology , obstetrics , abortion , unexplained infertility , female infertility , reproductive medicine , biology , genetics
Purpose To investigate potential indicators of in vitro fertilization (IVF) treatment outcome for female infertility patients aged ≥ 40 years based on the clinical course. Methods We retrospectively examined results of 111 female infertility patients aged ≥ 40 years undergoing IVF treatment. We investigated the relationship between treatment cycle cancellation and the final outcome of IVF treatment in female infertility patients aged ≥ 40 years. Results A total of 44 pregnancies were achieved. Overall pregnancy rate per initiated treatment cycle was 12.1%, and 24 spontaneous abortions occurred (54.5%). No woman aged ≥ 45 years achieved pregnancy. No patients conceived after 10 treatment cycles while 42 (11.5%) oocyte pick‐up cycles and 120 (33.0%) embryo transfer cycles were canceled. Investigation of correlation with treatment cycle cancellation revealed that patients who experienced embryo transfer cancellation had a high spontaneous abortion rate while only a few patients who experienced oocyte pick‐up cancellation achieved pregnancy and even fewer achieved a successful outcome. Conclusions Our study suggests that, in addition to patient age and number of treatment cycles, cancellation of treatment cycle also provides another useful indicator for pregnancy outcome.