Open AccessEarly testing of insulin resistance: a tale of two lipid ratios in a group of 5th graders screened by the Coronary Artery Risk Detection in Appalachian Communities Project (CARDIAC Project)
Author(s) -
Charles Ituka Mosimah,
Christa Lilly,
Awung-Njia Forbin,
Pamela J. Murray,
Lee A. Pyles,
Emani C. Elliot,
William A. Neal
Publication year - 2019
Publication title -
world journal of pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 33
ISSN - 1867-0687
DOI - 10.1007/s12519-018-00225-z
Subject(s) - insulin resistance , medicine , homeostatic model assessment , overweight , triglyceride , insulin , body mass index , endocrinology , high density lipoprotein , acanthosis nigricans , logistic regression , receiver operating characteristic , gastroenterology , cholesterol
In West Virginia (WV), 47% of fifth-grade children are either overweight or obese. There is no clear consensus regarding the definition of insulin resistance in children, and directly measuring insulin on the population level is costly. Two proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) ratio. The purpose of this study is to examine the relationship between TRIG/HDL-C ratio, TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN).