Open AccessTacrolimus Induced Diabetic Ketoacidosis Following Hematopoietic Stem Cell Transplantation
Author(s) -
Shubham Sharma,
Divya Doval,
Vipin Khandelwal,
Meet Kumar,
Deepak Choudhary
Publication year - 2019
Publication title -
indian journal of hematology and blood transfusion/indian journal of hematology and blood transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.213
H-Index - 15
eISSN - 0974-0449
pISSN - 0971-4502
DOI - 10.1007/s12288-019-01113-w
Subject(s) - diabetic ketoacidosis , medicine , tacrolimus , transplantation , diabetes mellitus , hematopoietic stem cell transplantation , ketoacidosis , stem cell , type 1 diabetes , surgery , endocrinology , biology , genetics
Risk of diabetes mellitus increases after solid organ and hematopoietic stem cell transplantation. Diabetic ketoacidosis has been reported after solid organ transplantation in patients receiving tacrolimus but has rarely been reported after stem cell transplantation. The major risk factors for diabetic ketoacidosis are immunosuppressive drugs used after transplantation. We report here three cases of allogenic stem cell transplant who developed diabetic ketoacidosis while on treatment with tacrolimus. The drug was stopped in all the cases and patients were treated with insulin therapy resulting in complete recovery from diabetic ketoacidosis.