Open AccessSubcellular localization of EZH2 phosphorylated at T367 stratifies metaplastic breast carcinoma subtypes
Author(s) -
Emily R McMullen,
Stephanie L. Skala,
María E. González,
Sabra Djomehri,
Darshan S. Chandrashekar,
Sooryanarayana Varambally,
Celina G. Kleer
Publication year - 2020
Publication title -
breast cancer
Language(s) - English
Resource type - Journals
eISSN - 1880-4233
pISSN - 1340-6868
DOI - 10.1007/s12282-020-01189-7
Subject(s) - subcellular localization , metaplastic carcinoma , pathology , cytoplasm , cancer research , biology , breast cancer , downregulation and upregulation , mesenchymal stem cell , immunohistochemistry , cancer , medicine , microbiology and biotechnology , gene , biochemistry , genetics
Metaplastic carcinoma is an aggressive, triple-negative breast cancer (TNBC) with differentiation towards squamous, spindle, or mesenchymal cell types. The molecular underpinnings of the histological subtypes are unclear. Our lab discovered a cytoplasmic function of EZH2, a transcriptional repressor, whereby pEZH2 T367 binds to cytoplasmic proteins in TNBC cells and enhances invasion and metastasis. Here, we investigated the expression and subcellular localization of pEZH2 T367 protein in metaplastic carcinomas.