Open AccessPolygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
Author(s) -
JianBo Yang,
Yan Zheng,
Jin Ren,
Zhong Dai,
ShuangCheng Ma,
Aiguo Wang,
YaLun Su
Publication year - 2017
Publication title -
archives of pharmacal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.855
H-Index - 87
eISSN - 1976-3786
pISSN - 0253-6269
DOI - 10.1007/s12272-016-0816-7
Subject(s) - polygonum , polygonaceae , chemistry , traditional medicine , botany , biology , medicine
Seven new dianthrone glycosides, named polygonumnolides A1-B3 (1-7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1-4 showed moderate cytotoxicity.