Open AccessBiological Toxicity of the Compositions in Electronic-Cigarette on Cardiovascular System
Author(s) -
Lo Lai,
Hongyu Qiu
Publication year - 2020
Publication title -
journal of cardiovascular translational research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 51
eISSN - 1937-5395
pISSN - 1937-5387
DOI - 10.1007/s12265-020-10060-1
Subject(s) - electronic cigarette , nicotine , organ system , human health , toxicity , environmental health , medicine , cardiovascular health , toxicology , microbiology and biotechnology , pharmacology , biology , disease , psychiatry , pathology
Using electronic cigarette (e-cig) among youth is becoming a critical public health crisis in the USA. However, the biological impacts of the e-cig on multiple organ systems, especially in the cardiovascular system, are largely unknown. Unlike conventional tobacco, e-cig combines various chemical ingredients including nicotine and other add-on non-nicotine chemicals, such as the solvents (propylene glycol and/or vegetable glycerin) and flavoring chemicals, which dramatically increases the diversity of the potential implications. The recent outbreak of e-cig vaping-related tragic deaths in youth and multiple hospitalized patients raised a question on the safety of e-cig use and led to an urgent need for the knowledge of the health risk of the e-cig compositions. Therefore, in the review, we summarized the latest findings from both human and animal studies on the potential cardiovascular toxicological effects of e-cig on the cardiovascular system in terms of the systemic physiological implications and the cellular and molecular mechanisms involved.