Open AccesscFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors
Author(s) -
Fan Wang,
Wenjie Sun,
Lei Chang,
Kun Sun,
Leying Hou,
Lin-na Qian,
Chaoyin Jin,
Jiandong Chen,
Jiali Pu,
Panmeng Ye,
Shuang Qiu,
Jianhong Luo,
Shumin Duan,
Baorong Zhang,
Zhihua Gao,
Xiaojun Hu
Publication year - 2021
Publication title -
neuroscience bulletin/neuroscience bulletin
Language(s) - English
Resource type - Journals
eISSN - 1673-7067
pISSN - 1995-8218
DOI - 10.1007/s12264-021-00744-2
Subject(s) - expression (computer science) , neuroscience , web application , aggression , function (biology) , psychology , computer science , biology , social psychology , world wide web , evolutionary biology , programming language
cFos is one of the most widely-studied genes in the field of neuroscience. Currently, there is no systematic database focusing on cFos in neuroscience. We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice, comprising 398 brain nuclei and sub-nuclei, and five associated behaviors: pain, fear, feeding, aggression, and sexual behavior. Direct relationships among behaviors and nuclei (even cell types) under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications. Moreover, overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized, leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits. Using the analysis function of cFos-ANAB, multi-layered pictures of networks and their relationships can quickly be explored depending on users' purposes. These features provide a useful tool and good reference for early exploration in neuroscience. The cFos-ANAB database is available at www.cfos-db.net .