Open AccessThe Relationship Between Neuroimmunity and Bipolar Disorder: Mechanism and Translational Application
Author(s) -
Zhiang Niu,
Lu Yang,
Xiaohui Wu,
Yuncheng Zhu,
Jun Chen,
Yiru Fang
Publication year - 2019
Publication title -
neuroscience bulletin/neuroscience bulletin
Language(s) - English
Resource type - Journals
eISSN - 1673-7067
pISSN - 1995-8218
DOI - 10.1007/s12264-019-00403-7
Subject(s) - neurology , pathogenesis , immune system , medicine , mechanism (biology) , neuroscience , pathological , neurotrophic factors , bipolar disorder , tumor necrosis factor alpha , inflammation , cytokine , etiology , immunology , bioinformatics , psychology , psychiatry , cognition , receptor , biology , philosophy , epistemology
Neuroimmune system may be involved in the pathological process of bipolar disorder (BD), but the essential association is not fully understood. Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system (CNS). Meanwhile, neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized, such as neurotransmitter systems, neuroendocrine systems, neurotrophic factors, and oxidative stress. Simultaneously, related genes and immune changes in peripheral blood vary with it. Overall, neuroimmunity may play an important role in the pathogenesis of BD, and the inflammatory cytokines, especially interleukin-6 and tumor necrosis factor-alpha, have potential value for the clinical diagnosis and prognosis of BD, as well as predicting the therapeutic effects of drugs. Large-scale studies are needed to extend the evidence on neuroimmunity in BD, and to examine its clinical value for applications such as early prediction and treatment.