Open AccessCarboxypeptidase E (NF-α1): a new trophic factor in neuroprotection
Author(s) -
Yong Cheng,
Niamh X. Cawley,
Y. Peng Loh
Publication year - 2014
Publication title -
neuroscience bulletin/neuroscience bulletin
Language(s) - English
Resource type - Journals
eISSN - 1673-7067
pISSN - 1995-8218
DOI - 10.1007/s12264-013-1430-z
Subject(s) - neuroprotection , pain medicine , neuroscience , carboxypeptidase , receptor , pharmacology , neurology , biology , microbiology and biotechnology , medicine , enzyme , biochemistry , anesthesiology , anesthesia
Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.