Open AccessB16 Melanoma Cancer Cells with Higher Metastatic Potential are More Deformable at a Whole-Cell Level
Author(s) -
Yoshihiro Ujihara,
Daichi Ono,
Koki Nishitsuji,
Megumi Ito,
Shukei Sugita,
Masanori Nakamura
Publication year - 2021
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-021-00677-w
Subject(s) - actin , cancer cell , melanoma , protein filament , extracellular matrix , cancer , metastasis , cell , cell culture , chemistry , microbiology and biotechnology , biophysics , materials science , cancer research , biology , biochemistry , genetics
Metastasis is a process in which cancer cells spread from the primary focus site to various other organ sites. Many studies have suggested that reduced stiffness would facilitate passing through extracellular matrix when cancer cells instigate a metastatic process. Here we investigated the compressive properties of melanoma cancer cells with different metastatic potentials at the whole-cell level. Differences in their compressive properties were analyzed by examining actin filament structure and actin-related gene expression.