Open AccessEnhancement of Radio-Thermo-Sensitivity of 5-Iodo-2-Deoxyuridine-Loaded Polymeric-Coated Magnetic Nanoparticles Triggers Apoptosis in U87MG Human Glioblastoma Cancer Cell Line
Author(s) -
Samideh Khoei,
Vahid Hosseini,
Mehdi Hosseini,
Sepideh Khoee,
Sakine Shirvalilou,
Seied Rabi Mahdavi,
Jalil Pirayesh Islamian
Publication year - 2021
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-021-00675-y
Subject(s) - prussian blue , hyperthermia , polyethylene glycol , apoptosis , chemistry , cell culture , nanoparticle , mtt assay , radiosensitivity , peg ratio , magnetic nanoparticles , biophysics , materials science , nanotechnology , radiation therapy , biochemistry , medicine , biology , surgery , electrode , finance , economics , electrochemistry , genetics
With an emphasis on the radioresistant nature of glioblastoma cells, the aim of the present study was to evaluate the radio-thermo-sensitizing effects of PCL-PEG-coated Superparamagnetic iron oxide nanoparticles (SPIONs) as a carrier of 5-iodo-2-deoxyuridine (IUdR) in monolayer culture of U87MG human glioma cell line.