Open AccessEffects of Alzheimer’s Disease-Related Proteins on the Chirality of Brain Endothelial Cells
Author(s) -
Haokang Zhang,
Jie Fan,
Zhen Zhao,
Qianqian Wang,
Leo Q. Wan
Publication year - 2021
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-021-00669-w
Subject(s) - chirality (physics) , progressive supranuclear palsy , microbiology and biotechnology , biology , neuroscience , medicine , disease , pathology , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
Cell chirality is an intrinsic cellular property that determines the directionality of cellular polarization along the left-right axis. We recently show that endothelial cell chirality can influence intercellular junction formation and alter trans-endothelial permeability, depending on the uniformity of the chirality of adjacent cells, which suggests a potential role for cell chirality in neurodegenerative diseases with blood-brain barrier (BBB) dysfunctions, such as Alzheimer's disease (AD). In this study, we determined the effects of AD-related proteins amyloid-β (Aβ), tau, and apolipoprotein E4 (ApoE4) on the chiral bias of the endothelial cell component in BBB.