Open AccessDroplet Microfluidics with Reagent Micromixing for Investigating Intrinsic Platelet Functionality
Author(s) -
Maaike S. A. Jongen,
Paul M. Holloway,
Simon I. R. Lane,
Nicola A. Englyst,
Owen J. T. McCarty,
Jonathan West
Publication year - 2021
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-020-00665-6
Subject(s) - platelet , platelet activation , gpvi , paracrine signalling , population , microfluidics , chemistry , computational biology , microbiology and biotechnology , nanotechnology , receptor , immunology , biophysics , biology , materials science , biochemistry , medicine , environmental health
Precision mapping of the functional structure of platelet populations holds great promise for the identification of hyper-reactive subtypes that are likely to be disease drivers, having value in prognostics and as therapeutic targets. However, the ability to measure the intrinsic functional capacity of individual platelets is confounded by potent paracrine cross-talk, resulting in phenotypic remodeling of the entire platelet population, and in doing so obscuring the identity of hyper-reactive platelets.