Open AccessGeneral Characteristics of Microbubble-Adenovirus Vectors Carrying Genes
Author(s) -
Linqi Yang,
Juan Ma,
Lina Guan,
Yuming Mu
Publication year - 2020
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-020-00663-8
Subject(s) - gene , gene delivery , bone morphogenetic protein 2 , virus , viral vector , transfection , genetic enhancement , flow cytometry , biology , microbiology and biotechnology , computational biology , virology , recombinant dna , genetics , in vitro
Transferring genes safely, targeting cells and achieving efficient transfection are urgent problems in gene therapy that need to be solved. Combining microbubbles (MBs) and viruses to construct double vectors has become a promising approach for gene delivery. Understanding the characteristic performance of MBs that carry genes is key to promoting effective gene transfer. Therefore, in this study, we constructed MB-adenovirus vectors and discussed their general characteristics.