Open AccessScaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner
Author(s) -
Gennifer Chiou,
Elysa Jui,
Allison C. Rhea,
Aparna Gorthi,
Solaleh Miar,
Francisca M. Acosta,
Cynthia A. Perez,
Yasir Suhail,
. Kshitiz,
Yidong Chen,
Joo L. Ong,
Rena Bizios,
Christopher R. Rathbone,
Teja Guda
Publication year - 2020
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-020-00648-7
Subject(s) - scaffold , mesenchymal stem cell , fibrin , self healing hydrogels , tissue engineering , chemistry , microbiology and biotechnology , biomedical engineering , morphogenesis , extracellular matrix , matrix (chemical analysis) , mechanotransduction , bone morphogenetic protein 2 , biophysics , biology , in vitro , immunology , biochemistry , medicine , chromatography , organic chemistry , gene
Volumetric tissue-engineered constructs are limited in development due to the dependence on well-formed vascular networks. Scaffold pore size and the mechanical properties of the matrix dictates cell attachment, proliferation and successive tissue morphogenesis. We hypothesize scaffold pore architecture also controls stromal-vessel interactions during morphogenesis.