Open AccessShear-Induced Platelet Activation is Sensitive to Age and Calcium Availability: A Comparison of Adult and Cord Blood
Author(s) -
Jawaad Sheriff,
Lisa Malone,
Cecilia Avila,
Amanda Zigomalas,
Danny Bluestein,
Wadie F. Bahou
Publication year - 2020
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-020-00628-x
Subject(s) - platelet , cord blood , extracellular , calcium , platelet activation , p selectin , calcium in biology , umbilical cord , thrombin , chemistry , endocrinology , medicine , microbiology and biotechnology , immunology , biology
Antiplatelet therapy for neonates and infants is often extrapolated from the adult experience, based on limited observation of agonist-induced neonatal platelet hypoactivity and poor understanding of flow shear-mediated platelet activation. Therefore, thrombotic events due to device-associated disturbed flow are inadequately mitigated in critically ill neonates with indwelling umbilical catheters and infants receiving cardiovascular implants.