Open AccessEarly Intervention in Ischemic Tissue with Oxygen Nanocarriers Enables Successful Implementation of Restorative Cell Therapies
Author(s) -
Ludmila DiazStarokozheva,
Devleena Das,
Xiangming Gu,
Jordan Moore,
Luke R. Lemmerman,
Ian L. Valerio,
Heather M. Powell,
Natalia HiguitaCastro,
Michael R. Go,
Andre F. Palmer,
Daniel GallegoPerez
Publication year - 2020
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-020-00621-4
Subject(s) - necrosis , medicine , ischemia , reprogramming , nanocarriers , cell , pathology , pharmacology , chemistry , drug , biochemistry
Tissue ischemia contributes to necrosis and infection. While angiogenic cell therapies have emerged as a promising strategy against ischemia, current approaches to cell therapies face multiple hurdles. Recent advances in nuclear reprogramming could potentially overcome some of these limitations. However, under severely ischemic conditions necrosis could outpace reprogramming-based repair. As such, adjunctive measures are required to maintain a minimum level of tissue viability/activity for optimal response to restorative interventions.