Open AccessTransplantation of IL-10-Overexpressing Bone Marrow-Derived Mesenchymal Stem Cells Ameliorates Diabetic-Induced Impaired Fracture Healing in Mice
Author(s) -
Keze Cui,
Yuanliang Chen,
Haibo Zhong,
Nan Wang,
Lihui Zhou,
Fusong Jiang
Publication year - 2019
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-019-00608-w
Subject(s) - mesenchymal stem cell , medicine , bone healing , diabetes mellitus , transplantation , bone marrow , streptozotocin , inflammation , bone fracture , femoral fracture , endocrinology , femur , immunology , pathology , surgery , radiology
Diabetes mellitus is characterized by hyperglycemia which displays insufficiency or resistance to insulin. One of the complications of diabetes is the increased risk of fracture and the impairment of bone repair and regulation. There have been evidences from previous studies that mesenchymal stem cells (MSCs) from bone marrow promote cartilage and callous formation. In addition, IL-10, an anti-inflammatory cytokine, has been observed to relieve inflammation-related complications in diabetes.