Open AccessSynergistic Adhesiveness of Fibronectin with PHSRN Peptide in Gelatin Mixture Promotes the Therapeutic Potential of Human ES-Derived MSCs
Author(s) -
Hye-Seon Kim,
Sung Hyun Choi,
Mee Joo Kang,
Ki-Won Lee,
Ki Nam Kim,
HakJoon Sung
Publication year - 2019
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-019-00604-0
Subject(s) - mesenchymal stem cell , fibronectin , regenerative medicine , extracellular matrix , microbiology and biotechnology , adipose tissue , gelatin , cell culture , stem cell , chemistry , biology , biochemistry , genetics
Mesenchymal stem cells (MSCs) are promising candidates for cell therapy owing to their therapeutic effect in various diseases. In general, MSCs grow efficiently in serum-containing culture media, indicating an essential role of adhesion in their mesenchymal lineage-specific propagation. Nevertheless, the use of non-human supplements in culture (xeno-free issue) in addition to the lack of control over unknown factors in the serum hampers the clinical transition of MSCs.