Synergistic Adhesiveness of Fibronectin with PHSRN Peptide in Gelatin Mixture Promotes the Therapeutic Potential of Human ES-Derived MSCs | Zendy

Hye-Seon Kim | Zendy; Sung Hyun Choi | Zendy; MiLan Kang | Zendy; Kiwon Lee | Zendy; Ki-Nam Kim | Zendy; HakJoon Sung | Zendy

Open Access

Synergistic Adhesiveness of Fibronectin with PHSRN Peptide in Gelatin Mixture Promotes the Therapeutic Potential of Human ES-Derived MSCs

Author(s) -

Hye-Seon Kim,

Sung Hyun Choi,

MiLan Kang,

Kiwon Lee,

Ki-Nam Kim,

HakJoon Sung

Publication year - 2019

Publication title -

cellular and molecular bioengineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.668

H-Index - 34

eISSN - 1865-5033

pISSN - 1865-5025

DOI - 10.1007/s12195-019-00604-0

Subject(s) - fibronectin , gelatin , mesenchymal stem cell , peptide , chemistry , microbiology and biotechnology , extracellular matrix , biochemistry , biology

Mesenchymal stem cells (MSCs) are promising candidates for cell therapy owing to their therapeutic effect in various diseases. In general, MSCs grow efficiently in serum-containing culture media, indicating an essential role of adhesion in their mesenchymal lineage-specific propagation. Nevertheless, the use of non-human supplements in culture (xeno-free issue) in addition to the lack of control over unknown factors in the serum hampers the clinical transition of MSCs.

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