Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function | Zendy

Matthew H. Wilson | Zendy; Ruth Ann Veach | Zendy; Wentian Luo | Zendy; Richard C. Welch | Zendy; Shuvo Roy | Zendy; William H. Fissell | Zendy

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Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function

Author(s) -

Matthew H. Wilson,

Ruth Ann Veach,

Wentian Luo,

Richard C. Welch,

Shuvo Roy,

William H. Fissell

Publication year - 2019

Publication title -

cellular and molecular bioengineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.668

H-Index - 34

eISSN - 1865-5033

pISSN - 1865-5025

DOI - 10.1007/s12195-019-00601-3

Subject(s) - function (biology) , volume (thermodynamics) , computer science , biology , microbiology and biotechnology , physics , quantum mechanics

Bioengineering an implantable artificial kidney (IAK) will require renal epithelial cells capable of reabsorption of salt and water. We used genome engineering to modify cells for improved Na + /H + exchange and H 2 O reabsorption. The non-viral piggyBac transposon system enables genome engineering cells to stably overexpress one or more transgenes simultaneously.

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