Open AccessDesign of a Cytocompatible Hydrogel Coating to Modulate Properties of Ceramic-Based Scaffolds for Bone Repair
Author(s) -
Settimio Pacelli,
Sayantani Basu,
Cory Berkland,
Jinxi Wang,
Arghya Paul
Publication year - 2018
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-018-0521-3
Subject(s) - materials science , coating , self healing hydrogels , ceramic , gelatin , tissue engineering , brittleness , swelling , chemical engineering , composite material , biomedical engineering , chemistry , polymer chemistry , medicine , biochemistry , engineering
Physical and mechanical properties of ceramic-based scaffolds can be modulated by introducing hydrogel coatings on their surface. For instance, hydrogels can be used as elastic layers to overcome the brittleness of synthetic ceramic materials or to control the delivery of essential osteogenic factors. In this work, we aimed to achieve both goals by fabricating a novel cytocompatible hydrogel made of gelatin-alginate as a coating for beta-tricalcium phosphate (β-TCP) scaffolds.