Open AccessEffect of Spatial Heterogeneity and Colocalization of eNOS and Capacitative Calcium Entry Channels on Shear Stress-Induced NO Production by Endothelial Cells: A Modeling Approach
Author(s) -
Kenneth A. Barbee,
Jaimit Parikh,
Yien Liu,
Donald G. Buerk,
Dov Jaron
Publication year - 2018
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-018-0520-4
Subject(s) - colocalization , shear stress , microbiology and biotechnology , enos , shear (geology) , biophysics , calcium , chemistry , biology , materials science , physics , nitric oxide , mechanics , endocrinology , nitric oxide synthase , composite material , organic chemistry
Colocalization of endothelial nitric oxide synthase (eNOS) and capacitative Ca 2+ entry (CCE) channels in microdomains such as cavaeolae in endothelial cells (ECs) has been shown to significantly affect intracellular Ca 2+ dynamics and NO production, but the effect has not been well quantified.