Open AccessAn Experimentally Determined State Diagram for Human CD4+ T Lymphocyte CXCR4-Stimulated Adhesion Under Shear Flow
Author(s) -
Nicholas Anderson,
Dong Hoon Lee,
Daniel A. Hammer
Publication year - 2018
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-018-0519-x
Subject(s) - shear (geology) , adhesion , shear flow , flow (mathematics) , cxcr4 , diagram , computer science , mechanics , immunology , biology , materials science , physics , immune system , composite material , database , chemokine
The leukocyte adhesion cascade is important for the maintenance of homeostasis and the ability of immune cells to access sites of infection and inflammation. Despite much work identifying the molecular components of the cascade, and numerous simulations to predict the relationship between molecule density, identity, and adhesion, these relationships have not been measured experimentally.