The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition | Zendy

Shweta Sharma | Zendy; Rishov Goswami | Zendy; Shaik O. Rahaman | Zendy

Open Access

The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition

Author(s) -

Shweta Sharma,

Rishov Goswami,

Shaik O. Rahaman

Publication year - 2018

Publication title -

cellular and molecular bioengineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.668

H-Index - 34

eISSN - 1865-5033

pISSN - 1865-5025

DOI - 10.1007/s12195-018-00565-w

Subject(s) - mechanotransduction , microbiology and biotechnology , epithelial–mesenchymal transition , mesenchymal stem cell , transforming growth factor , trpv4 , matrix (chemical analysis) , transition (genetics) , nanotechnology , chemistry , materials science , biology , ion channel , biochemistry , gene , receptor , chromatography

The implantation of biomaterials into soft tissue leads to the development of foreign body response, a non-specific inflammatory condition that is characterized by the presence of fibrotic tissue. Epithelial-mesenchymal transition (EMT) is a key event in development, fibrosis, and oncogenesis. Emerging data support a role for both a mechanical signal and a biochemical signal in EMT. We hypothesized that transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive channel, is a mediator of EMT.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research