Open AccessThe TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition
Author(s) -
Shweta Sharma,
Rishov Goswami,
Shaik O. Rahaman
Publication year - 2018
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-018-00565-w
Subject(s) - mechanotransduction , mechanosensitive channels , epithelial–mesenchymal transition , microbiology and biotechnology , trpv4 , chemistry , signal transduction , mesenchymal stem cell , extracellular matrix , transforming growth factor , fibrosis , downregulation and upregulation , biology , receptor , transient receptor potential channel , pathology , medicine , biochemistry , ion channel , gene
The implantation of biomaterials into soft tissue leads to the development of foreign body response, a non-specific inflammatory condition that is characterized by the presence of fibrotic tissue. Epithelial-mesenchymal transition (EMT) is a key event in development, fibrosis, and oncogenesis. Emerging data support a role for both a mechanical signal and a biochemical signal in EMT. We hypothesized that transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive channel, is a mediator of EMT.