Open AccessMechanical Response of an Epithelial Island Subject to Uniaxial Stretch on a Hybrid Silicone Substrate
Author(s) -
Yashar Bashirzadeh,
Sandeep Dumbali,
Shizhi Qian,
Venkat Maruthamuthu
Publication year - 2018
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-018-00560-1
Subject(s) - silicone , substrate (aquarium) , subject (documents) , materials science , nanotechnology , composite material , computer science , biology , ecology , world wide web
The mechanical response of large multi-cellular collectives to external stretch has remained largely unexplored, despite its relevance to normal function and to external challenges faced by some tissues. Here, we introduced a simple hybrid silicone substrate to enable external stretch while providing a physiologically relevant physical micro-environment for cells.