Open AccessGenerating Chondromimetic Mesenchymal Stem Cell Spheroids by Regulating Media Composition and Surface Coating
Author(s) -
BanuPriya Sridharan,
Amy D. Laflin,
Michael S. Detamore
Publication year - 2017
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-017-0517-4
Subject(s) - spheroid , mesenchymal stem cell , chondrogenesis , microbiology and biotechnology , aggrecan , tissue engineering , chemistry , glycosaminoglycan , stem cell , extracellular matrix , biomedical engineering , biology , biochemistry , pathology , articular cartilage , in vitro , medicine , alternative medicine , osteoarthritis
Spheroids of mesenchymal stem cells (MSCs) in cartilage tissue engineering have been shown to enhance regenerative potential owing to their 3D structure. In this study, we explored the possibility of priming spheroids under different media to replace the use of inductive surface coatings for chondrogenic differentiation.
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