Open AccessCell Migration in Microfabricated 3D Collagen Microtracks is Mediated Through the Prometastatic Protein Girdin
Author(s) -
Aniqua Rahman-Zaman,
Shuo Shan,
Cynthia A. ReinhartKing
Publication year - 2017
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-017-0511-x
Subject(s) - microbiology and biotechnology , cell migration , nanotechnology , chemistry , cell , materials science , biology , biochemistry
In vivo , cancer cells can utilize tube-like microtracks formed within the extracellular matrix (ECM) of the stroma as 'highways' to escape the primary tumor, however very little is known about the molecular mechanisms that govern cell migration through these microtracks. Cell polarization and actin organization are both essential for efficient cell migration and cells are known to migrate very unidirectionally in confined spaces. In this study, we focused on understanding the role of Girdin during unidirectional migration. Girdin is a prometastatic protein known to be involved in cell polarity by directly interacting with the cell polarity protein Par-3 (Partitioning defective-3) and also known as an actin binding protein.