Open AccessOvarian and Breast Cancer Migration Dynamics on Laminin and Fibronectin Bi-directional Gradient Fibers Fabricated via Multiphoton Excited Photochemistry
Author(s) -
Visar Ajeti,
Jorge Lara-Santiago,
Samuel Alkmin,
Paul J. Campagnola
Publication year - 2017
Publication title -
cellular and molecular bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.668
H-Index - 34
eISSN - 1865-5033
pISSN - 1865-5025
DOI - 10.1007/s12195-017-0492-9
Subject(s) - fibronectin , laminin , cell migration , extracellular matrix , dynamics (music) , metastasis , breast cancer , microbiology and biotechnology , actin cytoskeleton , cell , chemotaxis , matrix (chemical analysis) , chemistry , computer science , cytoskeleton , biophysics , materials science , biology , cancer , physics , receptor , biochemistry , genetics , chromatography , acoustics
Migration mis-regulation is a hallmark of cancer, and remains an important problem in cancer biology. We postulate the needs for better in vitro models to understand the details of cell-matrix interactions. Here, we utilized multiphoton excited (MPE) photochemistry to fabricate models to systematically study migration dynamics operative in breast and ovarian cancer. Gradients are a convenient means to modulate concentration and also have been implicated in metastases.