Open AccessO-GlcNAcylation: the “stress and nutrition receptor” in cell stress response
Author(s) -
Yang Liu,
Ruizhi Yao,
Shuai Lian,
Peng Liu,
YangGen Hu,
Hongzhao Shi,
Hongming Lv,
Yuyu Yang,
Bin Xu,
Shize Li
Publication year - 2021
Publication title -
cell stress and chaperones
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.994
H-Index - 87
eISSN - 1466-1268
pISSN - 1355-8145
DOI - 10.1007/s12192-020-01177-y
Subject(s) - microbiology and biotechnology , signal transduction , autophagy , cellular stress response , transcription factor , biology , crosstalk , homeostasis , unfolded protein response , proteasome , receptor , fight or flight response , apoptosis , genetics , gene , endoplasmic reticulum , physics , optics
O-GlcNAcylation is an atypical, reversible, and dynamic glycosylation that plays a critical role in maintaining the normal physiological functions of cells by regulating various biological processes such as signal transduction, proteasome activity, apoptosis, autophagy, transcription, and translation. It can also respond to environmental changes and physiological signals to play the role of "stress receptor" and "nutrition sensor" in a variety of stress responses and biological processes. Even, a homeostatic disorder of O-GlcNAcylation may cause many diseases. Therefore, O-GlcNAcylation and its regulatory role in stress response are reviewed in this paper.