Open AccessAstaxanthin supplementation impacts the cellular HSP expression profile during passive heating
Author(s) -
Chen Fleischmann,
Netta Bar-Ilan,
Michal Horowitz,
Yaron Bruchim,
Patricia A. Deuster,
Yuval Heled
Publication year - 2020
Publication title -
cell stress and chaperones
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.994
H-Index - 87
eISSN - 1466-1268
pISSN - 1355-8145
DOI - 10.1007/s12192-019-01061-4
Subject(s) - astaxanthin , heat shock protein , antioxidant , carotenoid , oxidative stress , hsp27 , heat stress , heat shock , food science , chemistry , haematococcus pluvialis , hsp70 , biology , biochemistry , zoology , gene
Astaxanthin is a powerful carotenoid antioxidant prevalent in marine organisms and approved as a food supplement. Recent studies have demonstrated Astaxanthin's beneficial attributes in various health states. Following initial reports of potential heat protective properties in Astaxanthin supplemented rats, we present here results of a novel study examining the effect of Astaxanthin supplementation on the heat shock response in rats in relation to core temperature (Tc) and the ensuing physiological strain. Two hours of heat stress at 41 °C during which rats developed their thermoregulatory hyperthermic plateau resulted in progressive increases in HSP72 and HSP27 in the Astaxanthin (Oleoresin)-treated group but not in the control (Olive oil) group. Enhanced elevation in HSPs suggests that Astaxanthin supplementation may augment the cellular stress protective response to heat stress.