Open AccessRosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature
Author(s) -
Aileen AzariYaam,
Mohammad Reza Abdolsalehi,
Mohammad Vasei,
Mohammadreza Safavi,
Mehrzad Mehdizadeh
Publication year - 2020
Publication title -
head and neck pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 50
eISSN - 1936-0568
pISSN - 1936-055X
DOI - 10.1007/s12105-020-01183-7
Subject(s) - rosai–dorfman disease , cervical lymphadenopathy , medicine , presentation (obstetrics) , differential diagnosis , sinus histiocytosis with massive lymphadenopathy , malignancy , disease , dermatology , emperipolesis , otorhinolaryngology , pathology , rare disease , radiology , surgery
Rosai-Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.