Open AccessSolitary Fibrous Tumour of Thyroid: Report of Two Cases with Immunohistochemical Features and Literature Review
Author(s) -
Giuseppe Santeusanio,
S. Schiaroli,
Angela Ortenzi,
Antonino Mulé,
Giuseppe Perrone,
Guido Fadda
Publication year - 2008
Publication title -
head and neck pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 50
eISSN - 1936-0568
pISSN - 1936-055X
DOI - 10.1007/s12105-008-0070-5
Subject(s) - solitary fibrous tumor , pathology , cd99 , cd34 , vimentin , differential diagnosis , nodular fasciitis , desmin , immunohistochemistry , cd31 , hemangiopericytoma , thyroid , medicine , thyroid carcinoma , biology , genetics , stem cell
Solitary fibrous tumour (SFT) is a rare tumour principally found in adults in the pleural cavity. Extrapleural occurrences are rare. Two cases of SFT of the thyroid gland are described in this paper showing their distinctive microscopical architecture, namely "patternless growth pattern". It is characterized by a bland spindle-cell proliferation alternating hyper- and hypo-cellular areas, keloid-like hyalinization and a focal hemangiopericytoma-like vascular pattern. Tumour cells revealed a diffuse strong positivity for CD34, CD99, bcl-2 and Vimentin, but negativity for Desmin, EMA, AE1/AE3, SMA, S-100 and CD31 antibodies. The differential diagnosis of thyroid SFT includes different types of spindle cell proliferation, benign and malignant mesenchymal tumours, medullary thyroid carcinoma, fasciitis-like papillary carcinoma, and undifferentiated (anaplastic) carcinoma. However, the morphologic and immunohistochemical findings of SFT are so characteristic that this diagnosis seldom represent a difficulty.