Open AccessAntiherpetic Effect of Topical Formulations Containing Sulfated Polysaccharide from Adenanthera pavonina
Author(s) -
Daniele Zendrini Rechenchoski,
Karoline Fontana Agostinho,
Lígia Carla Faccin-Galhardi,
Audrey Alesandra Stinghen Garcia Lonni,
Arcelina Pacheco Cunha,
Nágila Maria Pontes Silva Ricardo,
Carlos Nozawa,
Rosa Elisa Carvalho Linhares
Publication year - 2019
Publication title -
indian journal of microbiology/indian journal of microbiology (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 46
eISSN - 0973-7715
pISSN - 0046-8991
DOI - 10.1007/s12088-019-00815-z
Subject(s) - chemistry , polysaccharide , traditional medicine , medicine , biochemistry
Adenanthera pavonina is a native tree of Africa and Asia, introduced in Brazil for reforestation and wood industry. Several pharmacological activities have described scientifically, including antiviral activity. This study evaluated the antiviral effect of sulfated polysaccharide of Adenanthera pavonina (SP Ap ) against acyclovir (ACV)-resistant (AR-29) and sensitive (KOS) herpes simplex virus strains. The 50% cytotoxic concentration (CC 50 ) was determined by MTT method and the 50% inhibitory concentration (IC 50 ) was evaluated by plaque reduction assay. The in vivo SP Ap antiviral activity was performed in Balb/c mice infected by skin scarification and treated with topical 0.5% (w/w) SP Ap formulations. SP Ap showed a CC 50 of 47.81 μg/mL and the IC 50 were 0.49 μg/mL (SI = 97.5) and 0.54 μg/mL (SI = 88.5) for the strains KOS and AR-29, respectively. Our results demonstrated that mice treated with SP Ap presented a delay in the development and progression of skin lesions compared with the control group.