Open AccessBlisters on your fingers
Author(s) -
Leask Andrew
Publication year - 2021
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-021-00626-2
Subject(s) - mesenchymal stem cell , scleroderma (fungus) , connective tissue , fibrosis , medicine , progenitor cell , pathology , pathological , connective tissue disease , progenitor , immunology , disease , autoimmune disease , biology , stem cell , microbiology and biotechnology , inoculation
Mesenchymal progenitor cells play a key role in fibrogenesis. An exciting paper was recently published showed that blister fluid from the skin patients with the autoimmune connective tissue disease scleroderma (systemic sclerosis, SSc) preferentially activated mesenchymal progenitor cells (Taki et al. in Arthritis Rheumatol 72(8):1361–1374, 2020). These data provide new and invaluable insights into the complex interactions in the connective tissue microenvironment that ultimately result in persistent, pathological fibrosis.