Open AccessThe role of vascular endothelial protein tyrosine phosphatase on nitric oxide synthase function in diabetes: from molecular biology to the clinic
Author(s) -
Justo Alberto Fernando Oliveira,
Afonso Pedro Paulo Luciano
Publication year - 2021
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-021-00611-9
Subject(s) - enos , endothelial nitric oxide synthase , protein tyrosine phosphatase , nitric oxide , nitric oxide synthase , nitric oxide synthase type iii , medicine , endothelium , diabetes mellitus , endocrinology , type 2 diabetes , phosphatase , receptor , chemistry , biochemistry , enzyme
Endothelial nitric oxide synthase (eNOS) and receptor‐type vascular endothelial protein tyrosine phosphatase (VE‐PTP) are one of the majors signaling pathways related to endothelial health in diabetes. Several reports have shown that the inhibition of VE‐PTP can lead the nitric oxide production, although repeated studies showed that VE‐PTP regulated the eNOS exclusive at Ser1177 in indirect‐manner. A recent, exciting paper (Siragusa et al. in Cardiovasc Res, 2020. https://doi.org/10.1093/cvr/cvaa213 ), showing that VE‐PTP regulates eNOS in a direct‐manner, dephosphorylating eNOS at Tyr81 and indirect at Ser1177 and the effects of a VE‐PTP inhibitor, AKB‐9778, in the blood pressure from diabetic patients.