Open AccessGasdermin family: a promising therapeutic target for cancers and inflammation‐driven diseases
Author(s) -
Wu Danbin,
Chen Yefei,
Sun Yingxin,
Gao Qing,
Yu Bin,
Jiang Xijuan,
Guo Maojuan
Publication year - 2020
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-020-00564-5
Subject(s) - inflammation , medicine , bioinformatics , immunology , biology
This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore‐forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation‐driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.