Open AccessAsparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis
Author(s) -
Natasha Kamal,
Christopher Koh,
Niharika Samala,
Robert J. Fontana,
Andrew Stolz,
Francisco Durazo,
Paul H. Hayashi,
Elizabeth Phillips,
Tongrong Wang,
Jay H. Hoofnagle
Publication year - 2019
Publication title -
hepatology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.304
H-Index - 45
eISSN - 1936-0541
pISSN - 1936-0533
DOI - 10.1007/s12072-019-09971-2
Subject(s) - medicine , gastroenterology , jaundice , cholestasis , steatosis , liver injury , liver biopsy , hepatology , abdominal pain , bilirubin , liver function tests , biopsy
L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). The unique features of this hepatotoxicity are described.